Many translated example sentences containing “eritropoyetina recombinante” – English-Spanish dictionary and search engine for English translations. La farmacocinética de la eritropoyetina recombinante humana en pacientes con nefropatía endémica de los Balcanes. The Pharmacokinetics of Recombinant. Efecto del tratamiento con eritropoyetina recombinante humana sobre la necesidad de transfusión sanguínea en los pacientes críticos. Effect of human.

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You can change the settings or obtain more information by clicking here. Universidad de Santiago de Compostela. Eur J Haematol ; Recombinants total of 24 subjects was selected from the population of hemodialysis patients according to the following inclusion criteria: The significance of differences between mean values for groups was calculated using the Mann-Whitney U test and Student’s t-test.

Are you a health professional able to prescribe or dispense drugs? European best practice guidelines working group: Srp arh cel lek ; The results were expressed as mean values with standard deviations. The present study was initiated from earlier data involving BEN and 94 non-BEN patients, which showed that significantly higher beta-Epo doses for reaching and maintaining target hemoglobin level were necessary in BEN than in non-BEN patients.

Among the remaining 96 patients 40 BEN and 56 others who rrecombinante inclusion criteria, 10 with BEN and 14 with other kidney diseases were selected using systematic sampling i. After beta-Epo administration plasma Epo slowly increased and C max was achieved after A number of pharmacokinetic studies of ESA have been published, but comparison between them is difficult due eritdopoyetina numerous methodological differences.

SRJ is a prestige metric based on the idea that not all citations are the same. Introduction Anemia was described as a characteristic of Balkan endemic nephropathy BEN in early reports on the disease, 1,2 so Danilovic 3 included it among the criteria for diagnosis.


As the main organs involved in Epo elimination are the kidneys and bone marrow and both kidney function and bone marrow cellularity decrease with age, the authors suggested that age and creatinine influence Epo elimination. Although basal plasma Epo concentration was similar in BEN You can change the settings or obtain more information by clicking here.

In addition, iron status was assessed and supplementary iron given according to the same guidelines. Comparison of the pharmacokinetics of beta-erythropoietin given subcutaneously to hemodialysis patients with BEN or other kidney diseases non-BEN.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Our patients had iron reserves above the upper limit of normal and a similar proportion of subjects from each group used iron supplements. The group with other kidney diseases consisted of 8 patients with glomerulonephritis, 3 with hypertensive nephropathy, 2 with reflux nephropathy and 1 with polycystic kidney disease.

Eritropoyetina recombinante humana en la insuficiencia renal crónica

Pharmacokinetic analysis of subcutaneous erythropoietin administration with nonlinear mixed effect model including endogenous production. July Pages The utilization of rHuEp changed definitively the treatment and the natural history of anemia in patients with chronic renal insufficiency CRIand now is modifying the treatment of anemia of other non-renal patients as anemia of premature, anemia in onco-hematological illnesses, anemia in human immunodeficiency virus HIV infection, and for reduction of allogenic blood transfusions in surgery.

This finding needs to be confirmed in a well-controlled study with a larger sample size. This work was conducted as a part of projects No and funded by the Ministry of Science, Education and Technological Development, Belgrade, Republic of Serbia. Today Balkan endemic nephropathy is a disease of the elderly with a good prognosis.


Blood samples were centrifuged for 10 min and plasma stored frozen recomvinante analysis. Si continua navegando, consideramos que acepta su uso.

Balkan endemic nephropathy BEN hemodialysis patients require a higher dose of recombinant human erythropoietin for maintaining target hemoglobin level than patients with other kidney diseases. Erythropoietin is reported as an ingredient of Eritropoyetina Humana Recombinante Delta in the following countries:. Reecombinante work is licensed under a Creative Commons Attribution 4. Conflicts of interest The authors declare that they have no conflicts of interest related to the contents of this article.

A comparison of the bioequivalence of two formulations of epoetin alfa after subcutaneous injection. The pharmacokinetic parameters of Epo are presented in Table 3.

Are you a health professional able to prescribe or dispense drugs? Analysis of covariance ANCOVA was used to adjust these differences rexombinante patient characteristics that differed between groups: Si continua navegando, consideramos que acepta su uso.

Renal function, protein excretion and pathology of Balkan endemic nephropathy. This item has received. Erythropoietin resistance and survival in non-dialysis patients with stage chronic kidney disease and heart disease.

We recently showed that BEN hemodialysis patients erritropoyetina a higher dose of recombinant human erythropoietin for maintaining the target hemoglobin level than patients with other kidney diseases.